This study describes the formulation and evaluation of mucoadhesive buccal gels for curcumin delivery via buccal mucosa. In the present study the polymer with well-defined mucoadhesive properties like carbopol 934 was used. Carbopol- poloxamer gels of 1% curcumin was formulated with various absorption enhancers like polyethylene glycol, mannitol and sodium lauryl sulphate by cold method. Since curcumin is having bioavailability problem it has been formulated in gel form using absorption enhancers like polyethylene glycol, mannitol and sodium lauryl sulphate. The gels were characterized for gelation temperature, pH, viscosity, drug release profile, kinetic analysis of drug release data, drug content and stability studies. Sodium lauryl sulphate was found to be better absorption enhancer as compared to other absorption enhancers as it was showing better % drug release.
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